Monday, April 29, 2013

Sony Xperia Tablet Z now up for pre-order, scheduled to ship May 24th (video)

Xperia Tablet Z

If you've been waiting for the least burdensome tablet you could find, Sony's 17.5 ounce, 6.9mm thick Xperia Tablet Z is now up for pre-order in the US. On top of being the lightest, slimmest 10-inch slate on the market, it's not exactly slumming spec-wise either: there's a 1.5GHz quad-core Snapdragon processor, Android 4.1.2 Jelly Bean, 2GB RAM, an 8.1-megapixel Exmor R camera, NFC, LTE, S-Force virtual surround sound, 32GB storage and a 10.1-inch 1,920 x 1,200 display with Mobile BRAVIA Engine 2 tech. To round it off, the tab is dust- and water-resistant, and Sony's pre-loaded its TV SideView app, which uses the built-in IR to let you change your TV's channel and get scheduling, recommendations, voice search and IMDB-like info. The downside? We noted that the ambitiously thin design made the device a bit bendy and creaky, and then there's the $600 price tag -- frugal shoppers need not apply. You can pre-order at the source, or check the video after the break to see how a three-legged dog might use the slate while taking a bath. No, you didn't just misread that.

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Source: Sony Store

Source: http://www.engadget.com/2013/04/29/sonys-xperia-tablet-z-up-for-pre-order/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Apple declines to fix vulnerability in Safari's Web Archive files, likely because it requires user action to exploit

Apple declines to fix vulnerability in Safari's webarchive files, likely because it requires user action to exploit

Metasploit software developer Joe Vennix has detailed a vulnerability in Safari?s webarchive file format along with how it can be exploited. The post on Rapid7 indicates that after being reported to Apple back in February, the bug was closed last month with a status of ?wontfix?, indicating that Apple has no plans to address the bug. So what is it and why is that?

In Safari, if you go to save a web page, one of the options for the format to use is Web Archive. In many browsers when you save a web page locally, it only consists of the HTML source code itself. This means that any images, embedded videos, linked stylesheets or JavaScript will be lost. When you open a copy of the locally saved page, it will be missing all of the additional content, often not showing much more than text from the page and broken images. Safari?s Web Archive format works by not only saving the HTML of the page, but any linked content. When you open a Web Archive file, you will see the page as it would have originally appeared on the Internet, with all images, styling, and linked content preserved.

The bug found in Safari?s security model is a lack of restriction on what data can be accessed by the files in the web archive. Normally a page like Apple.com would be restricted to reading cookies that belonged to only the apple.com domain. It could not read cookies from another domain, such as Gmail.com. This is critical because if all of your cookies were readable by any website, it would be trivial for a malicious site to send your cookies back to an attacker, who could then log in to your accounts on any number of websites. In the case of Safari?s web archives, it?s possible for a malicious web archive to not only access content storied by another site, but potentially any file on the victim?s computer.

With such a serious sounding vulnerability, you might be wondering why Apple wouldn?t want to fix it? The answer seems to be that an exploit like this cannot be accomplished without user action. You couldn?t actually be affected by this unless you were to download and open a malicious .webarchive file. Users can avoid being attacked by employing the age old advice of not opening strange files from the Internet (or anywhere for that matter). That said, some people still do and surely will continue to do so. Given the potential impact of a vulnerability like this on users, it certainly seems like something Apple would want to fix at some point.

If you?re interesting in understanding more about how this bug works or can be exploited, Joe?s blog post covers several real world examples of how it could be used.

Source: Rapid 7

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/Pe35DEfi3F4/story01.htm

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Sunday, April 28, 2013

Previous specialist snowboarder and member of the infamous ...

Former professional snowboarder and member of the well known Wildcats, JF Pelchat is obviously seeking to discover Ray Ban Sunglasses Outlet?better approaches to boost goods although enjoying yourself. As early as 1990, he constructed his 1st set of two groundless board bindings after seeing a peek at a holding that?s scheduled to be sold one year later. Subsequently, http://www.shoprbsunglasses.com Pelchat has transferred from Quebec to Whistler to check out his aspiration and go to Craig?s Kelly World Snowboarding Camp out, labored within a board manufacturing facility, rode with the kind of the 2 Jeremy Smith, JP Walker, Devun Walsh, Travis Grain and Simon Richards to name a few. His Snowboarding career made it through for longer than fifteen years and through that time he adorned the covers and periodical internet pages of countless worldwide magazines and seemed in numerous board films.

Several of Pelchat?s career illustrates are: The Transworld Winter sports deal with in 1994, his very own Snowboarding seasoned designs, earning the Jose Cuervo Mug, highlighted in Mack Dawg?s films, visitor manager at Snowboarding Canada journal, member of the seasoned staff at Quicksilver and Dakine and as being a proud fellow member and person who owns the Wildcats.

Constantly functioning with his creates to boost goods, it wasn?t prior to the early on 2000s that the love for developing bindings increased. Realizing the gap and also the area for improvements in the holding section, he labored from his car port developing bindings along with a new concept. JF submitted is 1st evident in 2004 and commenced focusing on his second creation in 2006-which can be present day Now Dpo design.

Now Winter sports was in part produced when Pelchat and also the YES Snowboarding staff stood a evening assembly in the car port. Pelchat experienced went back from demonstrating his holding to some big players with no luck so he chose to present and explain the very idea of his new holding to his close friends. The next days they proceeded-hill for a few tests and so they all really appreciated the way the model executed so from then on they called their Europe companion, Nidecker Boards, and inquired the crooks to have a shut view it. Following researching the evident and also the model they consented to assist launch Now. Shortly after, Pelchat chosen veteran and product pro Alex Warburton to assist and load the roll of product boss and custom. Collectively along with the aid of engineer, Jesse Fernandez, they created the Now Dpo. Six many years has prior considering that the create of his 1st model and Pelchat is absolutely happy to see his product striking buyer fingers although taking board bindings one stage further.

Inquiries clarified by Chad Perrin, Movie director of Product sales, as informed to Transworld Winter sports Newspaper.
Do you know the largest trends framing the hardgoods industry for next season?For us it can be technological product development, an in general needed alternation in bindings that can adjust how men and women board.

Is there a finest adjust inside your manufacturer given that last season?Since this is a fresh manufacturer we haven?t experienced anything given that last season apart from taking a concept to see it receive fruition and getting over-departed about our product and manufacturer launch for your 12-13 season

How has got the market place developed throughout the last 12 months and how can you see things changing in the many years ahead?Makes along with stores have grown to be focused on product tales, building and purchasing exactly what they need to have environmentally friendly companies. Both have really clipped fat and also have turn out to be leaner, and general, with what has happened from Wall membrane E to Principal E, we as a possible business have grown to be old and figured out to reside in with much less and do business better using what we?ve got to make the best from much less.

How has sales forecasting altered for the company?We?ve been conversing within a restricted way with the repetitions and stores, even though we haven?t spilled every piece of information on our product and manufacturer, we?ve got discussed adequate information to know that we?ll see decent fresh out there overall performance.

What instruction have you ever figured out with concerns and generation because of this season and how would you use the crooks to next?Granted this is our fresh, we?re taking our group exposure to our other makes along with prior backgrounds and are only seeking to create to accommodate our prebooks, so product will probably be restricted to might know about market through the tradeshow season.

What size will be the traces destined to be in comparison to many years prior? Have you ever noticed customers puzzled by a lot of different tales?Our collection consists of 1 holding at 1 price which is a real product story and we?re centering on the technological facets of the holding because the principal system to share our story. A mix of the tech and also the staff which is backing NOW would have been a solid story, which makes it hard for people to disregard this device.

Source: http://www.cantegrilcountryclub.com/previous-specialist-snowboarder-and-member-of-the-infamous-wildcats-jf-pelchat-is-always-planning-to-find-low-cost-ray-ban-sunglasses-sunglasses-good-ways-to-enhance-products/

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Make Significantly more Capital In Affiliate Advertising and ...

Some affiliates who have been involved in affiliate?

Affiliate marketing added benefits each the web based company and the affiliate. With affiliate promoting, an via the internet small business will have an improve in website traffic on the web site, and, consequently, produce a great deal more sales. With affiliate marketing and advertising, an affiliate can earn revenue just by referring guests to the web page of the online home business. Every single client take a look at is converted to an agreed amount for the affiliate. But, does this come about normally?

Some affiliates who have been involved in affiliate promoting may possibly answer that the conversion of visits to income does not occur regularly sufficient. Are there also countless affiliates already? Of course not. The cyberspace has a limitless provide of clientele and their numberss are developing each second. There could in no way be also quite a few affiliates. But there are approaches in which a single affiliate can earn far more capital than his counterparts.

These methods have been proven time and again by affiliate marketing authorities. Hence, an affiliate will need to strategy to carry out these recommendations so that his revenue will greatly increase.

1. Study Search Engine Optimization

The target clients of affiliates are these that get inside cyberspace and surf the World wide web to acquire facts and goods. These target consumers can readily do the surfing and the looking by applying Search Engines. Therefore, the affiliate?s site need to unearth its way in the first benefits web page of a Search Engine.

The job now of the affiliate is to discover out how to have his web page listed and ranked higher by Search Engines and Directories. This is why the affiliate should study search engine optimization.

two. Have Great Content material

Affiliate promoting is not just about selling solutions or services. It is also providing helpful details to the target clientele. Thus, the affiliate ought to make certain that the articles discovered in his web page should certainly be info-laden.

If the target clientele finds the site beneficial, they will return to the affiliates website once again and once more, till they are convinced enough to proceed to the internet site of the internet home business. But if the client finds the affiliates web page is all flash and no substance, they will instantly come across yet another and far better internet site.

three. Promote A lot more Than One particular Product

A client likes to be given options. Therefore, the affiliate need to respond to this want of consumers. The website of the affiliate should certainly be providing choices to the client. Every selection will be described in terms of advantages and disadvantages. When alternatives are offered, convincing the client to patronize a particular product or service becomes less difficult.

four. Give Away Zero cost Items

The sensible affiliate should certainly construct loyalty from consumers by providing freebies. Such freebies may very well only be info that can be downloaded by the clientele.

With all the above suggestions becoming kept in the mind by the affiliate, his business enterprise of advertising will give him higher returns.

To know more about it, please go to: quality link building

Source: http://www.articlessquad.com/make-significantly-more-capital-in-affiliate-advertising-and-marketing/?utm_source=rss&utm_medium=rss&utm_campaign=make-significantly-more-capital-in-affiliate-advertising-and-marketing

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Friday, April 26, 2013

Instant View: Amazon profit beats Street view; sales forecast weak

SAN FRANCISCO (Reuters) - Amazon.com Inc's first-quarter revenue jumped 22 percent to $16.1 billion, propelled by growing sales of digital content, cloud-computing services and gains in retail. But it forecast weak sales this quarter, raising concerns about a slowing international business.

Commentary:

TOM FORTE, ANALYST, TELSEY ADVISORY GROUP

"This quarter is a bit of a 'tweener' so to speak: the company gave you a favorable margin, which is evident in both gross-margin performance and the upside in earnings, and then sales while not spectacular were good.

"Increase in third-party unit sales has been funding their gross margins.

"When I read the guidance for Q2 for operating margins, it suggests to me they're telegraphing that the company is going to continue a heightened rate of investment.

"Looking at the international performance, I think the message there is North America was better than expected but international was softer. The questions is: is this a reflection of macro trends in Europe, or is there something else going on there?"

VICTOR ANTHONY, ANALYST, TOPEKA CAPITAL MARKETS

"The fundamentals of the business improved significantly. So you saw a material improvement in gross margins, as well as a significant upside to estimates for their pro-forma operating margins. The trends are moving in the right direction fundamentally for the company.

"The high end of the guidance for revenue was above the Street. The pro-forma operating margins were slightly below the Street on the high end but they typically guide conservatively on that. Net, net it was a good print.

"The margins in international declined and that was a weak post.

"What we're seeing is that Amazon is really getting leverage from shipping costs. AWS is becoming a big part of their mix. They are also benefiting from a greater mix of advertising revenues. We'll continue to see that improve."

KEN SENA, ANALYST, EVERCORE

"The numbers came in relatively in-line.

"Guidance was maybe slightly disappointing. But when you look at the gross profit for the quarter, it beat expectations. They grew gross profit at 35 percent year-over-year.

"At the end of the day, at least on that basis, they are showing some very good progress. You are seeing benefit from the higher-margin Amazon Web Services business, and also higher-margin third-party marketplace business."

KERRY RICE, ANALYST, NEEDHAM & CO

"Gross margin is definitely better than expected. That is something that investors are certainly keen on.

"Guidance was light, both top- and bottom-line. That certainly won't help the stock perform, although they have over the last several quarters exceeded expectations on the operating income side. So for the guidance, people are more concerned about revenue than operating income."

(Reporting By Malathi Nayak and Poornima Gupta)

Source: http://news.yahoo.com/instant-view-amazon-profit-beats-street-view-sales-012225204--finance.html

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Thursday, April 25, 2013

The Samsung Galaxy S IV Reviews Are Great for the HTC One

With the Samsung Galaxy S IV set to go on sale this weekend on AT&T and in another month on Verizon, the reviewers have taken the purported iPhone killer for a spin and despite all its bells and whistles, they still like another Android phone a lot better. At its very dramatic Radio City debut, Samsung announced the successor to its very popular Galaxy S III, which included what looked like a few too many bells and whistles. And, it turns out, all the extra features weigh down an otherwise solid device, which means it a good phone, but not a "game changer," to use the words of Walt Mossberg over at AllThingsD. But, there is an Android "game changer" that almost all the gadget nerds brought up while reviewing the latest Galaxy S IV: The HTC One.?

RELATED: Samsung Takes the Secret-Gadget-Announcement Schtick Too Far

Looking for contrived, useless add-ons? The Galaxy S IV is the device for you, says Mossberg:?

If you?re a nut for lists of new features, love Samsung or crave an even bigger display, the Galaxy S 4 may be for you. It?s a good phone, just not a great one.

Not even the geeks are quite sure that's what they want out of a phone, admits Engadget's Brad Molen:

While our geek senses keep tingling at the thought of so many market-topping specs contained within the same chassis, we also aren't?overjoyed, per se, with excitement. The design doesn't feel fresh, especially not next to the HTC One, but we can't deny that it's an improvement over the GS3.

TechCrunch's Jordan Crook is certain it's not what he wants:

At the end of the day, it?d be foolish to think that the Galaxy S4 isn?t a top-notch phone. Where specs, performance and software innovation are concerned, the company is clearly making strides. But in playing with this phone for a while, adjusting to the new features, trying to make the most of them, and sometimes failing miserably, I keep returning to the idea of ?Keep it simple, stupid.?

If all the swiping and eye recognition stuff appeals to you, know that those things only work in Android's "crummy" browser, explains Wired's Michael Calore:

But all that business of waving your hand or moving your eyes to scroll while reading ? it only works in the crummy Android browser. It does not work in Chrome, where I do all of my browsing. It doesn?t work in Google Reader or Flipboard or Instapaper or the Kindle app, where so much reading happens. Looking away from the screen doesn?t pause a video in YouTube, only in the Samsung video player.

If you can get past that, however, this phone has a lot to offer, argues Ars Technica's Florence Ion:

None of this takes away from the performance of the Galaxy S 4, though. It's an?extremely?solid phone, and it's going to be hard to go back to the S III after a week with this one. It feels great to hold, it's comfortable to use throughout the day, and it takes much better photos than its predecessor. The aluminum ring on its chassis makes the handset look more modern than its predecessors. The display doesn't hurt either?it's really something to look at. Samsung definitely has another hit on its hands.

Although, it's build is a bit chintzy, counters Steve Kovach over at Business Insider:

As long as you don't mind a bunch of plastic, you'll be perfectly happy with the Galaxy S4.?

Ultimately, though, if you're in the market for an Android phone,?The Verge's David Pierce suggests?you?consider the HTC One:

The Galaxy S4 is fast and impressive, but it's also noisy and complex. The One is refined, quiet, comfortable, beautiful, and above all simply pleasant. I love using that phone, in a way I haven't experienced with anything since the iPhone 5. That's why, when my contract is up in June, I'll probably be casting my lot with HTC instead of Samsung.

... as does Mossberg:

I urge readers looking for a new Android smartphone to carefully consider the more polished-looking, and quite capable,?HTC One, rather than defaulting to the latest Samsung.

... as does The New York Times's David Pogue:

And the S4 is still made of plastic ? lightweight and grippy, but not as classy as the iPhone?s glass or the HTC One?s metal.

... as does Kovach:

But is it the best phone? No. You're still much better off with the iPhone 5 or the HTC One if you like Android.

,,, as does ABC News's Joanna Stern:

I just wish Samsung had put that same attention into the design of the physical phone. The HTC One and the iPhone 5 are simply better-designed and crafted pieces of hardware.

So, yeah, if you're going to get a new Android phone, consider the HTC One.?

RELATED: Samsung Drags the iPhone 5 Into the Apple Patent War

?

Source: http://news.yahoo.com/samsung-galaxy-iv-reviews-great-htc-one-144747459.html

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Women's Health Forum Preview- Weight Loss Champion | KTLA 5

Gayle Anderson was live in Lawndale to begin her contribution to the KTLA morning news ?Lose 5 With 5? month long health and fitness initiative. As part of this program, each Fitness Syndicate member was given one week with the contestants to train them for two to three days on various methods of fitness training.

Admission to the Women?s Health Forum is FREE, although you must register online by clicking HERE.?West Hall parking at the Los Angeles Convention Center is $12. For more information, call (310) 330-2235.?

13th Annual KJLH Women?s Health Forum
Saturday, April 27, 2013
Check-in begins at 7:00 a.m.?
8 a.m. to 3 p.m.?
Admission is FREE
Los Angeles Convention Center
1201 South Figueroa Street
Los Angeles, CA 90015
(310) 330-2235

If you want to follow Gayle?s ?Lose Five with Five? progress, you can contact Gayle via:
Twitter: @ KTLAGayle
Facebook: Gayle Anderson

If you have questions, please feel free to call Gayle Anderson at?323-460-5732?or e-mail Gayle at?Gayle.Anderson@KTLA.com.

Source: http://ktla.com/2013/04/24/womens-health-forum-weight-loss-champion/

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Personalizing prostate cancer screenings

Personalizing prostate cancer screenings [ Back to EurekAlert! ] Public release date: 24-Apr-2013
[ | E-mail | Share Share ]

Contact: Erin White
ewhite@northwestern.edu
847-491-4888
Northwestern University

Using genetic variants to improve PSA testing technique and reduce biopsies

CHICAGO --- With the help of genetics, prostate specific antigen (PSA) screenings may become more accurate and reduce the number of unnecessary prostate biopsies, according to a new study from Northwestern Medicine.

Personalized PSA testing using genetic variants could account for an 18 percent reduction in the number of men who likely would have undergone unnecessary biopsies, according to the study. It will be published in the May 2013 issue of The Journal of Urology.

The high survival rate of men with prostate cancer is largely a reflection of PSA testing, but support for the widespread use of the screening method has been the topic of recent debate because of its limited specificity.

"By utilizing a person's genetic makeup we can personalize care when he comes in for a PSA screening," said Brian Helfand, M.D., lead author of the study. "We may be able to prevent some men from having an unnecessary biopsy and prevent a delay in biopsy for men who may have an aggressive disease."

Helfand is an adjunct assistant professor of cell and molecular biology at Northwestern University Feinberg School of Medicine.

For 98 percent of the men, genetic adjustment of PSA levels did not change the outcome of their screening. But genetic correction was important for the 17 men who were reclassified as no longer meeting biopsy criteria and the three whose condition was up classified, and it was recommended they get a biopsy, based on their genetic adjustment.

"If our results are validated, genetic adjustments could potentially prevent 15 to 20 percent of prostate biopsies," said William J. Catalona, M.D., senior author of the study. "Since it has been estimated that more than 1 million biopsies are performed in the United States annually, this could translate into 150,000 to 200,000 potentially unnecessary biopsies every year."

In addition to cost savings, fewer biopsies mean fewer adverse outcomes, such as infection, sepsis and hospitalization, he said.

Catalona is a professor of urology at Feinberg, director of the clinical prostate cancer program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and an urologist at Northwestern Memorial Hospital.

Variants in genes, like those that help determine your height, are responsible for higher or lower levels of PSA expression. Recent studies have identified genetic variants associated with increased serum PSA concentrations, raising the possibility that a man's genetic make-up could interfere with an accurate PSA reading.

In this study, four variants previously associated with PSA levels were determined in 964 Caucasian volunteers without prostate cancer. Genetic correction of their PSA was performed by dividing each man's PSA value by his combined genetic risk. Analyses were used to compare the percentage of men who would meet commonly used biopsy thresholds (2.5 ng/ml or greater, or 4.0 ng/ml or greater) before and after genetic correction.

Assuming that a diagnostic laboratory has the available equipment, supplies and trained personnel, it would cost 60 cents per person to add genetic personalization to a PSA test.

The researchers are now investigating personalized PSA testing in black men and have plans to investigate genetic variants which impact PSA levels in other races as well.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Personalizing prostate cancer screenings [ Back to EurekAlert! ] Public release date: 24-Apr-2013
[ | E-mail | Share Share ]

Contact: Erin White
ewhite@northwestern.edu
847-491-4888
Northwestern University

Using genetic variants to improve PSA testing technique and reduce biopsies

CHICAGO --- With the help of genetics, prostate specific antigen (PSA) screenings may become more accurate and reduce the number of unnecessary prostate biopsies, according to a new study from Northwestern Medicine.

Personalized PSA testing using genetic variants could account for an 18 percent reduction in the number of men who likely would have undergone unnecessary biopsies, according to the study. It will be published in the May 2013 issue of The Journal of Urology.

The high survival rate of men with prostate cancer is largely a reflection of PSA testing, but support for the widespread use of the screening method has been the topic of recent debate because of its limited specificity.

"By utilizing a person's genetic makeup we can personalize care when he comes in for a PSA screening," said Brian Helfand, M.D., lead author of the study. "We may be able to prevent some men from having an unnecessary biopsy and prevent a delay in biopsy for men who may have an aggressive disease."

Helfand is an adjunct assistant professor of cell and molecular biology at Northwestern University Feinberg School of Medicine.

For 98 percent of the men, genetic adjustment of PSA levels did not change the outcome of their screening. But genetic correction was important for the 17 men who were reclassified as no longer meeting biopsy criteria and the three whose condition was up classified, and it was recommended they get a biopsy, based on their genetic adjustment.

"If our results are validated, genetic adjustments could potentially prevent 15 to 20 percent of prostate biopsies," said William J. Catalona, M.D., senior author of the study. "Since it has been estimated that more than 1 million biopsies are performed in the United States annually, this could translate into 150,000 to 200,000 potentially unnecessary biopsies every year."

In addition to cost savings, fewer biopsies mean fewer adverse outcomes, such as infection, sepsis and hospitalization, he said.

Catalona is a professor of urology at Feinberg, director of the clinical prostate cancer program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and an urologist at Northwestern Memorial Hospital.

Variants in genes, like those that help determine your height, are responsible for higher or lower levels of PSA expression. Recent studies have identified genetic variants associated with increased serum PSA concentrations, raising the possibility that a man's genetic make-up could interfere with an accurate PSA reading.

In this study, four variants previously associated with PSA levels were determined in 964 Caucasian volunteers without prostate cancer. Genetic correction of their PSA was performed by dividing each man's PSA value by his combined genetic risk. Analyses were used to compare the percentage of men who would meet commonly used biopsy thresholds (2.5 ng/ml or greater, or 4.0 ng/ml or greater) before and after genetic correction.

Assuming that a diagnostic laboratory has the available equipment, supplies and trained personnel, it would cost 60 cents per person to add genetic personalization to a PSA test.

The researchers are now investigating personalized PSA testing in black men and have plans to investigate genetic variants which impact PSA levels in other races as well.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/nu-ppc042413.php

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Wednesday, April 24, 2013

Huge elephant bird egg gets $101,813 at UK auction

Christie's scientific specialist James Hyslop poses for photographs with a sub-fossilized pre-17th century Elephant Bird egg at the auction house's premises in London, Wednesday, March 27, 2013. The egg, which is estimated to fetch 20,000 to 30,000 pounds ($30,210 to $45,315 and 23,645 to 35,467 euro) in the forthcoming Travel, Science and Natural History sale on April 24, measures over 100 times the average size of a chicken egg, and stands at 21cm in diameter and 30cm in height. The extinct Elephant Bird species was native to Madagascar and among the heaviest known birds. (AP Photo/Matt Dunham)

Christie's scientific specialist James Hyslop poses for photographs with a sub-fossilized pre-17th century Elephant Bird egg at the auction house's premises in London, Wednesday, March 27, 2013. The egg, which is estimated to fetch 20,000 to 30,000 pounds ($30,210 to $45,315 and 23,645 to 35,467 euro) in the forthcoming Travel, Science and Natural History sale on April 24, measures over 100 times the average size of a chicken egg, and stands at 21cm in diameter and 30cm in height. The extinct Elephant Bird species was native to Madagascar and among the heaviest known birds. (AP Photo/Matt Dunham)

(AP) ? A massive, partly fossilized egg laid by a now-extinct elephant bird has sold for more than double its estimate at a London auction.

Christie's auction house said Wednesday that the foot-long, nearly nine-inches in diameter egg fetched 66,675 pounds ($101,813). It had been valued at 20,000 to 30,000 pounds pre-sale, and was sold to an anonymous buyer over the telephone after about 10 minutes of competitive bidding.

Elephant birds were wiped out several hundred years ago. The oversized ovum, laid on the island of Madagascar, is believed to date back before the 17th century.

Flightless, fruit-gobbling elephant birds resembled giant ostriches and could grow to be 11 feet high (3.4 meters). Christie's says their eggs are 100 times the size of an average chicken's.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/aa9398e6757a46fa93ed5dea7bd3729e/Article_2013-04-24-EU-Britain-Big-Egg/id-c9294b209adc4f22982f77c77ce7a12c

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Genome Biology | Abstract | Interactions between immunity ...

Open Access Research

Srikanth Nagalla, Jeff W Chou, Mark C Willingham, Jimmy Ruiz, James P Vaughn, Purnima Dubey, Timothy L Lash, Stephen J Hamilton-Dutoit, Jonas Bergh, Christos Sotiriou, Michael A Black and Lance D Miller

For all author emails, please log on.

Genome Biology 2013, 14:R34?doi:10.1186/gb-2013-14-4-r34

Published: 24 April 2013

Abstract (provisional)

Background

Gene expression signatures indicative of tumor proliferative capacity and tumor-immune cell interactions have emerged as principal biology-driven predictors of breast cancer outcomes. How these signatures relate to one another in biological and prognostic contexts remains to be clarified.

Results

To investigate the relationship between proliferation and immune gene signatures, we analyzed an integrated dataset of 1,954 clinically-annotated breast tumor expression profiles randomized into training and test sets to allow two-way discovery and validation of gene-survival associations. Hierarchical clustering revealed a large cluster of distant metastasis-free survival-associated genes with known immunological functions that further partitioned into three distinct immune metagenes likely reflecting: B-cells and/or plasma cells;, T-cells and natural killer cells,;and monocytes and dendritic cells. A proliferation metagene allowed stratification of cases into proliferation tertiles. The prognostic strength of these metagenes was largely restricted to tumors within the highest proliferation tertile, though intrinsic subtype-specific differences were observed in the intermediate and low proliferation tertiles. In highly proliferative tumors, high-tertile immune metagene expression equated with reduced risk of metastasis while tumors with low-tertile expression of any one of the three immune metagenes were associated with poor outcome despite higher expression of the other two metagenes.

Conclusions

These findings suggest that a productive interplay among multiple immune cell types at the tumor site promotes long-term anti-metastatic immunity in a proliferation-dependent manner. The emergence of a subset of effective immune responders among highly proliferative tumors has novel prognostic ramifications.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Source: http://genomebiology.com/2013/14/4/R34

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Epigenetic changes shed light on biological mechanism of autism

Apr. 23, 2013 ? Scientists from King's College London have identified patterns of epigenetic changes involved in autism spectrum disorder (ASD) by studying genetically identical twins who differ in autism traits.

The study, published in Molecular Psychiatry, is the largest of its kind and may shed light on the biological mechanism by which environmental influences regulate the activity of certain genes and in turn contribute to the development of ASD and related behaviour traits.

ASD affects approximately 1 in 100 people in the UK and involves a spectrum of disorders which manifest themselves differently in different people. People with ASD have varying levels of impairment across three common areas: deficits in social interactions and understanding, repetitive behaviour and interests, and impairments in language and communication development.

Evidence from twin studies shows there is a strong genetic component to ASD and previous studies suggest that genes that direct brain development may be involved in the disorder. In approximately 70% of cases, when one identical twin has ASD, so does the other. However, in 30% of cases, identical twins differ for ASD. Because identical twins share the same genetic code, this suggests non-genetic, or epigenetic, factors may be involved.

Epigenetic changes affect the expression or activity of genes without changing the underlying DNA sequence -- they are believed to be one mechanism by which the environment can interact with the genome. Importantly, epigenetic changes are potentially reversible and may therefore provide targets for the development of new therapies.

The researchers studied an epigenetic mechanism called DNA methylation. DNA methylation acts to block the genetic sequences that drive gene expression, silencing gene activity. They examined DNA methylation at over 27,000 sites across the genome using samples taken from 50 identical twin pairs (100 individuals) from the UK Medical Research Council (MRC) funded Twins Early Development Study (TEDS): 34 pairs who differed for ASD or autism related behaviour traits, 5 pairs where both twins have ASD, and 11 healthy twin pairs.

Dr Chloe Wong, first author of the study from King's College London's Institute of Psychiatry, says: "We've identified distinctive patterns of DNA methylation associated with both autism diagnosis and related behaviour traits, and increasing severity of symptoms. Our findings give us an insight into the biological mechanism mediating the interaction between gene and environment in autism spectrum disorder."

DNA methylation at some genetic sites was consistently altered for all individuals with ASD, and differences at other sites were specific to certain symptom groups. The number of DNA methylation sites across the genome was also linked to the severity of autism symptoms suggesting a quantitative relationship between the two. Additionally, some of the differences in DNA methylation markers were located in genetic regions that previous research has associated with early brain development and ASD.

Professor Jonathan Mill, lead author of the paper from King's College London's Institute of Psychiatry and the University of Exeter, says: "Research into the intersection between genetic and environmental influences is crucial because risky environmental conditions can sometimes be avoided or changed. Epigenetic changes are potentially reversible, so our next step is to embark on larger studies to see whether we can identify key epigenetic changes common to the majority of people with autism to help us develop possible therapeutic interventions."

Dr Alycia Halladay, Senior Director of Environmental and Clinical Sciences from Autism Speaks who funded the research, says: "This is the first large-scale study to take a whole genome approach to studying epigenetic influences in twins who are genetically identical but have different symptoms. These findings open the door to future discoveries in the role of epigenetics -- in addition to genetics -- in the development of autism symptoms."

The study was funded by Autism Speaks, Medical Research Council UK (MRC) and the Brain and Behavior Research Foundation (NARSAD). The twins were selected from the Twins Early Development Study (TEDS) which is funded by the MRC with additional support from the US National Institutes of Health.

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The above story is reprinted from materials provided by King's College London.

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Journal Reference:

  1. C C Y Wong, E L Meaburn, A Ronald, T S Price, A R Jeffries, L C Schalkwyk, R Plomin, J Mill. Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Molecular Psychiatry, 2013; DOI: 10.1038/mp.2013.41

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/5SSPuYtQGZA/130423091113.htm

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Tuesday, April 23, 2013

Boston suspect's misspelled name tripped up FBI, senator says (cbsnews)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/300785530?client_source=feed&format=rss

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The Asian monsoon is getting predictable

The Asian monsoon is getting predictable [ Back to EurekAlert! ] Public release date: 23-Apr-2013
[ | E-mail | Share Share ]

Contact: Mario Aguilera
scrippsnews@ucsd.edu
858-534-3624
University of California - San Diego

Researchers find strong correlation between summer monsoon and the climate pattern that preceded it

For much of Asia, the pace of life is tuned to rhythms of monsoons.

The summer rainy season is especially important for securing the water and food supplies for more than a billion people. Its variations can mean the difference between drought and flood. Now a Scripps Institution of Oceanography, UC San Diego-led study reports on a crucial connection that could drastically improve the ability of forecasters to reliably predict the monsoon a few months in advance.

Yu Kosaka and Shang-Ping Xie from Scripps and colleagues from NOAA found that a winter appearance of the climate phenomenon called El Nio in the Pacific Ocean can leave its mark on monsoon formation in the Indian Ocean a full six months later. In between is an atmospheric phenomenon called the Pacific-Japan pattern that provides the teleconnection between the two ocean basins and further poleward to East Asia.

"It has long been a mystery that climate anomalies in the region correlate better with El Nio in the preceding winter than with the one developing in the concurrent summer," said Xie, a climate scientist and inaugural holder of the Scripps Roger Revelle Chair in Environmental Science. "The new paper shows that Indian Ocean temperature and atmospheric anomalies in the western Pacific are physically coupled, and their interactions amplify each other. We demonstrated that this new mode of coupled ocean-atmospheric anomalies is predictable a season ahead. Such predictions have tremendous benefits to society."

The National Science Foundation-funded study, "Origin of seasonal predictability for summer climate over the Northwestern Pacific," appears online on April 22 in Proceedings of the National Academy of Sciences. Ngar-Cheung Lau and Gabriel Vecchi of NOAA are also co-authors.

El Nio is a climate phenomenon coupling the ocean and atmosphere that includes a shift in the distribution of warm water in the equatorial Pacific Ocean. El Nio years are characterized by unusual weather and storm activity globally.

The summer after a major El Nio features above-average sea-surface temperatures in the Indian Ocean. El Nio exerts its influence via the Pacific-Japan pattern, which can bring to East Asia cool, wet weather in the subsequent summer, while La Nia leads to dry, hot weather.

The violent storm activity associated with El Nio takes place in the eastern Pacific Ocean, but the chain of events the researchers describe ultimately ends up being detected in the western Pacific Ocean. Xie likened it to an echo effect, saying that El Nio serves to pull clouds and convection eastward toward the International Date Line, which means those clouds are not available over the western Pacific to keep ocean surface temperatures cool. It also weakens winds in the northern Indian Ocean and the effects of those weakened winds travel back eastward to the Pacific Ocean.

"The last sound El Nio makes is in the western Pacific Ocean," Kosaka said, "because the positive feedback between the Indian Ocean and Pacific-Japan pattern we found amplifies climate anomalies in this region."

The last echoes of El Nio have devastating consequences to the region.

Extremes in the East Asian summer monsoon have been behind some of the largest natural and economic disasters to hit the region in the last 20 years. The authors note that excessive rains and cool temperature in Japan in 1993 caused a widespread failure of that country's rice crop that opened it to imports from other countries. Dry monsoon phases led to widespread heat waves and drought in several East Asian countries in 2004.

Kosaka cautioned, however, that there is much more work to be done to make prediction of the Asian monsoon reliable. El Nio is just one factor; other regional patterns complicate the sequence that ultimately produces monsoon rains, Kosaka said.

But the paper does establish that El Nio influences the monsoon and describes the means by which it does so, she said.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


The Asian monsoon is getting predictable [ Back to EurekAlert! ] Public release date: 23-Apr-2013
[ | E-mail | Share Share ]

Contact: Mario Aguilera
scrippsnews@ucsd.edu
858-534-3624
University of California - San Diego

Researchers find strong correlation between summer monsoon and the climate pattern that preceded it

For much of Asia, the pace of life is tuned to rhythms of monsoons.

The summer rainy season is especially important for securing the water and food supplies for more than a billion people. Its variations can mean the difference between drought and flood. Now a Scripps Institution of Oceanography, UC San Diego-led study reports on a crucial connection that could drastically improve the ability of forecasters to reliably predict the monsoon a few months in advance.

Yu Kosaka and Shang-Ping Xie from Scripps and colleagues from NOAA found that a winter appearance of the climate phenomenon called El Nio in the Pacific Ocean can leave its mark on monsoon formation in the Indian Ocean a full six months later. In between is an atmospheric phenomenon called the Pacific-Japan pattern that provides the teleconnection between the two ocean basins and further poleward to East Asia.

"It has long been a mystery that climate anomalies in the region correlate better with El Nio in the preceding winter than with the one developing in the concurrent summer," said Xie, a climate scientist and inaugural holder of the Scripps Roger Revelle Chair in Environmental Science. "The new paper shows that Indian Ocean temperature and atmospheric anomalies in the western Pacific are physically coupled, and their interactions amplify each other. We demonstrated that this new mode of coupled ocean-atmospheric anomalies is predictable a season ahead. Such predictions have tremendous benefits to society."

The National Science Foundation-funded study, "Origin of seasonal predictability for summer climate over the Northwestern Pacific," appears online on April 22 in Proceedings of the National Academy of Sciences. Ngar-Cheung Lau and Gabriel Vecchi of NOAA are also co-authors.

El Nio is a climate phenomenon coupling the ocean and atmosphere that includes a shift in the distribution of warm water in the equatorial Pacific Ocean. El Nio years are characterized by unusual weather and storm activity globally.

The summer after a major El Nio features above-average sea-surface temperatures in the Indian Ocean. El Nio exerts its influence via the Pacific-Japan pattern, which can bring to East Asia cool, wet weather in the subsequent summer, while La Nia leads to dry, hot weather.

The violent storm activity associated with El Nio takes place in the eastern Pacific Ocean, but the chain of events the researchers describe ultimately ends up being detected in the western Pacific Ocean. Xie likened it to an echo effect, saying that El Nio serves to pull clouds and convection eastward toward the International Date Line, which means those clouds are not available over the western Pacific to keep ocean surface temperatures cool. It also weakens winds in the northern Indian Ocean and the effects of those weakened winds travel back eastward to the Pacific Ocean.

"The last sound El Nio makes is in the western Pacific Ocean," Kosaka said, "because the positive feedback between the Indian Ocean and Pacific-Japan pattern we found amplifies climate anomalies in this region."

The last echoes of El Nio have devastating consequences to the region.

Extremes in the East Asian summer monsoon have been behind some of the largest natural and economic disasters to hit the region in the last 20 years. The authors note that excessive rains and cool temperature in Japan in 1993 caused a widespread failure of that country's rice crop that opened it to imports from other countries. Dry monsoon phases led to widespread heat waves and drought in several East Asian countries in 2004.

Kosaka cautioned, however, that there is much more work to be done to make prediction of the Asian monsoon reliable. El Nio is just one factor; other regional patterns complicate the sequence that ultimately produces monsoon rains, Kosaka said.

But the paper does establish that El Nio influences the monsoon and describes the means by which it does so, she said.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/uoc--tam042313.php

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'Breaking Bad,' 'Under the Dome' actor shows support for film ...

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WILMINGTON, NC (Twitter) -- As thousands gathered to take a stand for the state's film incentives Saturday, some famous actors filming in the Port City rallied support, too.

Dean Norris, known as Hank Schrader in AMC's series, "Breaking Bad," tweeted pictures and blurbs in support of the cause.

Norris, who's in town filming the upcoming TV series "Under the Dome," tweeted "NC film incentive rally! Downtown Wilmington," followed by a tweet that read, "Film = jobs," including a picture of himself at the event.

Area leaders and supporters at the rally say the film industry provides Wilmington with jobs and revenue, and they will continue to fight for the industry.

Click here to visit Norris' Twitter account.

Disclaimer: Comments posted on this, or any story are opinions of those people posting them, and not the views or opinions of WWAY NewsChannel 3, its management or employees. You can view our comment policy here.

?

Source: http://www.wwaytv3.com/2013/04/22/breaking-bad-under-the-dome-actor-shows-support-for-film-incentives-wilmington

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Monday, April 22, 2013

'American Psycho' musical to open in London

Kerry Hayes / AP

Christian Bale in the film "American Psycho."

By Belinda Goldsmith, Reuters

A musical based on Bret Easton Ellis's "American Psycho," the disturbing tale of a Wall Street banker turned sadistic serial killer, will have its world premiere in London in December.

A spokesman for London's Almeida Theatre said on Friday that the show would open on December 3 and run until January 25.

American playwright Roberto Aguirre-Sacasa, best known for his work on the U.S. television series "Glee," is producing the script and the show is directed by Briton Rupert Goold.

The music and lyrics will be produced by American singer-songwriter Duncan Sheik, who wrote the music for "Spring Awakening" but is best known for his 1996 debut single "Barely Breathing."

Easton Ellis's novel, published in 1991, is a satire about the 1980s yuppie boom and follows Wall Street investment banker Patrick Bateman, an obsessive materialist who by night commits murders -- or at least imagines he commits them -- while losing himself in drugs and prostitution.

On its release, "American Psycho" shocked readers with graphic content that included Bateman torturing a woman with a rat. In Australia the book was shrink-wrapped and could not be sold to anyone aged under 18.

The book was adapted into a film in 2000 starring Christian Bale, while a project to adapt the book into a musical for the United States was first announced in 2008.

Producer Jesse Singer said the team behind the musical had decided to move it to London where Goold is based and is associated with the Almeida Theatre and to try the show off-Broadway first.

Related content:

Source: http://todayentertainment.today.com/_news/2013/04/21/17850221-american-psycho-musical-to-premiere-in-britain?lite

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Finally, Revis a Buc (almost)

NFC Championship - San Francisco 49ers v Atlanta FalconsGetty Images

With the NFL Draft approaching, we?re taking a team-by-team look at the needs of each club. Up next is the team with the No. 30 overall selection, the Atlanta Falcons. They have a total of 11 picks, and aren?t afraid to make bold moves, so their picking somewhere north of 30 is a real possibility.

Defensive end: There?s already noise about the Falcons wanting to move up in the order, and it makes sense that their target would be a pass-rusher.

John Abraham was still producing right up until the time they released him, and they have to find someone to replace that production other than Osi Umenyiora, who has not produced at the same consistent level. If they can get into the top half of the first round, they can find someone in the Abraham mold, before the run starts.

Cornerback: This would be the other drastic need that could be the target for a move-up. It seems like forever ago they were three-deep with excellent players. But with Brent Grimes gone to Miami and and Dunta Robinson released and resurfaced in KC, they?re down to Asante Samuel and a bunch of guys.

Linebacker: You could probably run down the list of defensive positions, and the Falcons could stand to upgrade. Sean Weatherspoon is quite good, but the rest of their linebacking corps is fairly ordinary.

Tackle: The thinking is the release of Tyson Clabo opened the door for Lamar Holmes to start at right tackle, and that could work. But they still need cover here, particularly if newly rich left tackle Sam Baker goes back to the 2011 version instead of the 2012 salary-push version.

Guard: The retirement of Todd McClure leaves a big hole, but they could slide 2012 second-rounder Peter Konz over from right guard. But that leaves another vacancy. They have some in-house candidates, but need depth here.

As good as they are, they?re not as well-covered as you?d think. They have nothing to speak of in terms of depth on defense. Heck, they don?t even have a full complement of starting-caliber players on that side of the ball.

But their offensive skill-position talent is so good, it might not matter. As long as Matt Ryan, Steven Jackson, Julio Jones, Roddy White and Tony Gonzalez are together, the Falcons are going to be among the best in the NFC.

But until they get at least a little bit better on defense, it?s going to be hard for them to make the next step.

Their offseason efforts have focused on retaining their own, and making a few surgical signings of veterans who came looking for rings. Their team is good enough that 11 draft picks aren?t making their 53-man roster, so they might as well make some moves, and see if they can plug some starters in on defense.

Source: http://profootballtalk.nbcsports.com/2013/04/21/revis-deal-done-pending-physical/related/

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Interrogators wait to query wounded bomb suspect

Police officers stand near statues of former Boston Red Sox greats, from left, Ted Williams, Bobby Doerr, Johnny Pesky and Dom DiMaggio during a baseball game between the Kansas City Royals and the Boston Red Sox, the first game held in the city following the Boston Marathon explosions, Saturday, April 20, 2013, in Boston. Police captured Dzhokhar Tsarnaev, 19, the surviving Boston Marathon bombing suspect, late Friday, after a wild car chase and gun battle earlier in the day left his older brother dead. (AP Photo/Julio Cortez)

Police officers stand near statues of former Boston Red Sox greats, from left, Ted Williams, Bobby Doerr, Johnny Pesky and Dom DiMaggio during a baseball game between the Kansas City Royals and the Boston Red Sox, the first game held in the city following the Boston Marathon explosions, Saturday, April 20, 2013, in Boston. Police captured Dzhokhar Tsarnaev, 19, the surviving Boston Marathon bombing suspect, late Friday, after a wild car chase and gun battle earlier in the day left his older brother dead. (AP Photo/Julio Cortez)

This Friday, April 19, 2013 image made available by the Massachusetts State Police shows 19-year-old Boston Marathon bombing suspect, Dzhokhar Tsarnaev, hiding inside a boat during a search for him in Watertown, Mass. He was pulled, wounded and bloody, from the boat parked in the backyard of a home in the Greater Boston area. (AP Photo/Massachusetts State Police)

An official wearing SWAT gear walks behind a fenced off area outside of Fenway Park during a baseball game between the Kansas City Royals and the Boston Red Sox, the first game held in the city following the Boston Marathon explosions, Saturday, April 20, 2013, in Boston. Police captured Dzhokhar Tsarnaev, 19, the surviving Boston Marathon bombing suspect, late Friday, after a wild car chase and gun battle earlier in the day left his older brother dead. (AP Photo/Julio Cortez)

This Friday, April 19, 2013 image made available by the Massachusetts State Police shows 19-year-old Boston Marathon bombing suspect, Dzhokhar Tsarnaev, hiding inside a boat during a search for him in Watertown, Mass. He was pulled, wounded and bloody, from the boat parked in the backyard of a home in the Greater Boston area. (AP Photo/Massachusetts State Police)

This Friday, April 19, 2013 image made available by the Massachusetts State Police shows a police vehicle probing the boat where 19-year-old Boston Marathon bombing suspect, Dzhokhar Tsarnaev, was hiding in Watertown, Mass. He was pulled, wounded and bloody, from the boat parked in the backyard of a home in the Greater Boston area. (AP Photo/Massachusetts State Police)

BOSTON (AP) ? As the lone surviving suspect in the Boston Marathon bombing lay hospitalized under heavy guard, the American Civil Liberties Union and a federal public defender raised concerns about investigators' plan to question 19-year-old Dzhokhar Tsarnaev without reading him his Miranda rights.

What Tsarnaev will say and when are unclear ? he remained in serious condition and apparently in no shape for interrogation after being pulled bloody and wounded from a tarp-covered boat in a Watertown backyard. The capture came at the end of a tense Friday that began with his 26-year-old brother, Tamerlan, dying in a gunbattle with police.

U.S. officials said an elite interrogation team would question the Massachusetts college student without reading him his Miranda rights, something that is allowed on a limited basis when the public may be in immediate danger, such as instances in which bombs are planted and ready to go off.

ACLU Executive Director Anthony Romero said the legal exception applies only when there is a continued threat to public safety and is "not an open-ended exception" to the Miranda rule, which guarantees the right to remain silent and the right to an attorney.

The federal public defender's office in Massachusetts said it has agreed to represent Tsarnaev once he is charged. Miriam Conrad, public defender for Massachusetts, said he should have a lawyer appointed as soon as possible because there are "serious issues regarding possible interrogation."

There was no immediate word on when Tsarnaev might be charged and what those charges would be. The twin bombings killed three people and wounded more than 180.

The most serious charge available to federal prosecutors would be the use of a weapon of mass destruction to kill people, which carries a possible death sentence. Massachusetts does not have the death penalty.

President Barack Obama said there are many unanswered questions about the bombing, including whether the Tsarnaev brothers ? ethnic Chechens from southern Russia who had been in the U.S. for about a decade and lived in the Boston area ? had help from others. The president urged people not to rush judgment about their motivations.

Gov. Deval Patrick said Saturday afternoon that Tsarnaev was in serious but stable condition and was probably unable to communicate. Tsarnaev was at Boston's Beth Israel Deaconess Medical Center, where 11 victims of the bombing were still being treated.

"I, and I think all of the law enforcement officials, are hoping for a host of reasons the suspect survives," the governor said after a ceremony at Fenway Park to honor the victims and survivors of the attack. "We have a million questions, and those questions need to be answered."

The all-day manhunt Friday brought the Boston area to a near standstill and put people on edge across the metropolitan area.

The break came around nightfall when a homeowner in Watertown saw blood on his boat, pulled back the tarp and saw a bloody Tsarnaev hiding inside, police said. After an exchange of gunfire, he was seized and taken away in an ambulance.

Raucous celebrations erupted in and around Boston, with chants of "USA! USA!" Residents flooded the streets in relief four days after the two pressure-cooker bombs packed with nails and other shrapnel went off.

Michael Spellman said he bought tickets to Saturday's Red Sox game at Fenway Park to help send a message to the bombers.

"They're not going to stop us from doing things we love to do," he said, sitting a few rows behind home plate. "We're not going to live in fear."

During the long night of violence leading up to the capture, the Tsarnaev brothers killed an MIT police officer, severely wounded another lawman and took part in a furious shootout and car chase in which they hurled explosives at police from a large homemade arsenal, authorities said.

Watertown Police Chief Edward Deveau said one of the explosives was the same type used during the Boston Marathon attack, and authorities later recovered a pressure cooker lid that had embedded in a car down the street. He said the suspects also tossed two grenades before Tamerlan ran out of ammunition and police tackled him.

But while handcuffing him, officers had to dive out of the way as Dzhokhar drove the carjacked Mercedes at them, Deveau said. The SUV dragged Tamerlan's body down the block, he said. Police initially tracked the escaped suspect by a blood trail he left behind a house after abandoning the Mercedes, negotiating his surrender hours later in the boat.

Chechnya, where the Tsarnaev family has roots, has been the scene of two wars between Russian forces and separatists since 1994. That spawned an Islamic insurgency that has carried out deadly bombings in Russia and the region, although not in the West.

Investigators have not offered a motive for the Boston attack. But in interviews with officials and those who knew the Tsarnaevs, a picture has emerged of the older one as someone embittered toward the U.S., increasingly vehement in his Muslim faith and influential over his younger brother.

The Russian FSB intelligence service told the FBI in 2011 about information that Tamerlan Tsarnaev was a follower of radical Islam, two law enforcement officials said Saturday.

According to an FBI news release, a foreign government said that Tamerlan Tsarnaev appeared to be strong believer and that he had changed drastically since 2010 as he prepared to leave the U.S. for travel to the Russian region to join unspecified underground groups.

The FBI did not name the foreign government, but the two officials said it was Russia. The officials spoke on condition of anonymity because they were not authorized to talk about the matter publicly.

The FBI said that in response, it interviewed Tamerlan Tsarnaev and relatives, and did not find any domestic or foreign terrorism activity. The bureau said it looked into such things as his telephone and online activity, his travels and his associations with others.

An uncle of the Tsarnaev brothers said he had a falling-out with Tamerlan over the man's increased commitment to Islam.

Ruslan Tsarni of Montgomery Village, Md., said Tamerlan told him in a 2009 phone conversation that he had chosen "God's business" over work or school. Tsarni said he then contacted a family friend who told him Tsarnaev had been influenced by a recent convert to Islam.

Tsarni said his relationship with his nephew basically ended after that call.

As for Dzhokhar Tsarnaev, "he's been absolutely wasted by his older brother. I mean, he used him. He used him for whatever he's done," Tsarni said.

Albrecht Ammon, a downstairs-apartment neighbor of Tamerlan Tsarnaev in Cambridge, said in an interview that the older brother had strong political views about the U.S. Ammon quoted Tsarnaev as saying that the U.S. uses the Bible as "an excuse for invading other countries."

Tamerlan Tsarnaev studied accounting as a part-time student at Bunker Hill Community College in Boston for three semesters from 2006 to 2008, the school said. He was married with a young daughter. Dzhokhar Tsarnaev was a student at the University of Massachusetts Dartmouth.

As of Saturday, more than 50 victims of the bombing remained hospitalized, three in critical condition.

___

Associated Press writers Denise Lavoie and Steve Peoples in Boston; Michael Hill in Watertown, Mass.; Colleen Long in New York; Pete Yost in Washington; Eric Tucker in Montgomery Village, Md.; and AP Sports Writer Jimmy Golen in Boston contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-21-Boston%20Marathon-Explosions/id-8028ba9c29d34b72879f1d636ff6b6c7

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